The consequences of PCOS are the subject of constant research, yet a number of scientific reports underlinethe fact that in women with PCOS, there appear higher risk of glucose intolerance and diabetes type2, hypertension, dislipidemia and atherosclerosis. The effects of PCOS reach beyond women’s reproductiveaxis. Metabolic syndrome occurs in 43-46% of patients with PCOS, which constitutes two times more than inwomen population. Insuline resistance and hyperinsulinemia are key disorders in both syndromes. Obesity,gestational diabetes, positive family history of diabetes type 2 and metabolic syndrome constitute a risk factorfor metabolic disorder development in patients with PCOS. Farmacological treatment of PCO syndrome dependson dominating symptoms and patient’s current needs taking into account her reproductive status. For a longtime, medicines which reduce insuline resistance have been used to treat PCOS, in ovulation stimulation as wellas in improvement of metabolic disorders. Insuline sensitivity improvement via reduction of body weight (diet,physical exercises) and choosing active lifestyle appears to be a standard.