Particulate pollution is a continual problem which is usually caused by the burning of crop residues in highland agricultural systems. The objectives of this study are to investigate crop-residue management and estimate the amount of pollutant emissions from burning crop residues for each land-use pattern (grain maize, seed maize and integrated farming), and to estimate the chemical compositions of PM2.5 emissions from agricultural burning in Mae Chaem basin, Chiang Mai Province, Thailand. The purposive sampling method was used for sample selection. A door-to-door questionnaire survey was used to obtain responses from 149 respondents. Greenhouse gas (GHG) emissions from the open burning of crop residues were estimated, using specific emission factors obtained from several literature reviews and from the field by the questionnaire survey. Results revealed that the majority of farmers burned maize residues during April and May and mostly in the afternoon. These burning behaviors are in line with the supportive weather conditions that reflect high values of temperature and wind speed, and less rainfall and relative humidity result in maize residues being burned easily and quickly. The integrated farming system generated the lowest GHG emissions and amount of chemical composition of PM2.5 emissions, followed by the grain maize and seed maize patterns, respectively. This study strongly supports the implementation of the integrated farming system in Mae Chaem basin. Proactive and reactive measures should be taken in a well-organized and systematic fashion and should engage all related parties. More importantly, there is an urgent need for policy makers to include PM2.5 concentrations to upgrade Thailand’s air-quality index (PM2.5 AQI).