New directions in animal husbandry demand raising of animal kinds that are adjusted to intensive way of breeding. In order to accomplish these demands, beside known methods in selection, Cytogenetic control of existing genotypes is needed that has been carried through ten year examination on pig, cattle and stud farms in Vojvodina. Chromosome aberration of numeric polyploidy and aneuploidy but also structural translocation, deletion, duplication, inversion, ring, break and other segregations were discovered. Numeric and structural changes on animal karyotype influenced on reproduction disturbance, phenotype expression, as well as selection program and stability of genofond. Different aspects of reproductive disturbance were noted like for example: small litter, embryo mortality, frequent repeated breeding, abortion, stillbirth and mummified embryo, offspring with anomalities, different kinds of sterility, Analyses of the results obtained from monitoring the herd book and making genealogy show on existence of chromosomepathy on our farms. The aim of this work is to inform scientists and experts with the fact that these changes are spreading, especially through among the breeding animals. Therefore genetic control and timely exclusion of chromosome aberration is necessary.