crl ubiquitin ligases and dna damage response
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crl ubiquitin ligases and dna damage response

;Jianping eJin;Ju-Mei eLi
international journal of heat and technology 2012 Vol. 2 pp. -
262
ejin2012frontierscrl

Abstract

Cullin/RING ubiquitin ligases (CRL) comprise the largest subfamily of ubiquitin ligases and are involved in various biological processes. One of the main functions of CRLs is to regulate DNA damage response, a fundamental signaling cascade to maintain genome integrity. In this review, we will discuss the regulation of CRL ubiquitin ligases and their roles in control of DNA damage response.

Keywords

dna damage cyclin d1 protein degradation cdc25a Oncology including cancer and carcinogens tumors

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DOI:
10.3389/fonc.2012.00029
URL:
http://journal.frontiersin.org/Journal/10.3389/fon...

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ID: 145998
Ref Key: ejin2012frontierscrl
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145998
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10.3389/fonc.2012.00029
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