Muhammet Kazim Erol,1 Ayse Balkarli,2 Ozgur Yucel,1 Yusuf Akar,3 Berna Dogan,1 Elcin Suren1 1Department of Ophthalmology, 2Department of Internal Medicine, Division of Rheumatology, Antalya Education and Research Hospital, 3Department of Ophthalmology, Akdeniz University Medical Faculty, Antalya, Turkey Purpose: This study aimed to evaluate mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) values and their relationship with clinical findings in patients with central serous chorioretinopathy (CSCR).Methods: Overall, 87 patients fulfilling inclusion criteria and 320 age- and sex-matched healthy individuals as controls were included in the study. The CSCR patients (n=87) were classified into 2 groups as acute CSCR (group 1, n=43) and chronic CSCR (group 2, n=44).Results: It was found that NLR (P<0.05) and C-reactive protein (CRP) (P<0.05) values were higher in acute CSCR group than the other groups. MPV value was found to be higher in chronic CSCR group than the other groups (P<0.001).Conclusion: It seems that neutrophils play a major role in acute CSCR while platelets are involved in progression to chronic CSCR. Larger, prospective studies are needed on this topic. Keywords: central serous chorioretinopathy, mean platelet volume, neutrophil/lymphocyte ratio