This study aimed to determine the effect of cognitive therapy and family psycho-education on prodromal psychosis and self-esteem of adolescents in the orphanages.A quasi experimental pre-post test with a control group design was used in this study. The participants were 77 adolescents selected through purposive sampling method. Data were analyzed using ANOVA test with repeated measures and t-test.The use of cognitive therapy and family psycho-education alleviated the symptoms of prodromal psychosis approaching the prodromal score level limit and increased self-esteem significantly p = 0.00 (p<0.05).Cognitive therapy and family psycho-education are recommended for adolescents living in orphanages who experience prodromal psychosis with low self-esteem.