The mechanical properties of lightweight aggregate concrete (LWAC) depend on the mixing ratio of its binders, normal weight aggregate (NWA), and lightweight aggregate (LWA). To characterize the relation between various concrete components and the mechanical characteristics of LWAC, extensive studies have been conducted, proposing empirical equations using regression models based on their experimental results. However, these results obtained from laboratory experiments do not provide consistent prediction accuracy due to the complicated relation between materials and mix proportions, and a general prediction model is needed, considering several mix proportions and concrete constituents. This study adopts the artificial neural network (ANN) for modeling the complex and nonlinear relation between constituents and the resulting compressive strength and elastic modulus of LWAC. To construct a database for the ANN model, a vast amount of detailed and extensive data was collected from the literature including various mix proportions, material properties, and mechanical characteristics of concrete. The optimal ANN architecture is determined to enhance prediction accuracy in terms of the numbers of hidden layers and neurons. Using this database and the optimal ANN model, the performance of the ANN-based prediction model is evaluated in terms of the compressive strength and elastic modulus of LWAC. Furthermore, these prediction accuracies are compared to the results of previous ANN-based analyses, as well as those obtained from the commonly used linear and nonlinear regression models.