An analysis has been carried out to study heat and mass transfer characteristics of an incompressible and Newtonian fluid having temperature-dependent fluid viscosity and thermophoresis particle deposition over a vertical stretching surface with variable stream condition. The Rosseland approximation is used to describe the radiative heat flux in the energy equation. The vertical surface is assumed to be permeable so as to allow for possible wall suction or injection. The governing differential equations are derived and transformed using Lie group analysis. The transformed equations are solved numerically by applying Runge-Kutta Gill scheme with shooting technique. Favorable comparisons with previously published work on various special cases of the problem are obtained. Numerical results for the velocity, temperature and concentration profiles for a prescribed temperature-dependent fluid viscosity and thermophoresis particle deposition parameters are presented graphically to elucidate the influence of the various physical parameters.