The interference of weeds in maize production may be reflected in grain yield losses that vary as a function of the density, stage and degree of aggressiveness of the species present. In the agricultural ecosystem, crops and weeds demand light, water, nutrients and space, which are frequently not available in sufficient quantities, leading to competition. The aim of this work was to determine the period of interference of weed plants, in particular of naked crabgrass (Digitaria nuda) on maize crop in the first and second harvest. The treatments were defined as increasing periods of coexistence and increasing control of weed community (7, 14, 21, 28, 35, 42, 49, and 56 days), two more controls, a control including one with weed control until the end of the culture cycle and another with coexistence until the harvest. For each period, were evaluated the stand of maize plants, length of ear, number of grains per row, number of rows per ear, cob, 100-grain weight, and grain productivity. The data obtained were subjected to analysis of variance using the F test, with average treatments compared using Tukey’s test at 5% probability. Crop productivity was evaluated by means of regressions, the critical periods of interference were estimated. The critical timing of weed removal was 25 days for both harvests. The critical weed free period was 54 and 27 days for the first and second harvest respectively. For the conditions of the first and second harvest, the critical period of weed control was of 29 and 2 days respectively.