When creating Triticum aestivum L. varieties in V. M. Remeslo Myronivka Institute of Wheat, intervarietal crossing was used as the basis for classical method of hybridization. Parental pairs were selected according to environmental and geographical principles. Crossing of lines selected by certain adaptive characteristics among themselves and with the local breeding varieties are widely used. The method of induced mutagenesis is one of the main factor of the evolutionary process which increases hundreds of times the frequency of altered forms occurrence. Thermal mutagenesis – selection of winter forms from spring varieties – is based on low temperature effect on spring wheat varieties (it was developed by V. M. Remeslo, the member of the Academy of Sciences). Method of intervarietal selection in winter wheat breeding provides creation of new varieties of this crop through mass selection of the best plants from local populations. At present, 10 varieties of winter wheat are included into the State Register of Plant Varieties Suitable for Dissemination in Ukraine, one variety – into the State Register of Breeding Achievements of the Russian Federation, seven varieties are passing state quality testing in these countries.