Objective: To explore effect of transcatheter arterial chemoembolization (TACE) on coagulation function, liver function and liver fibrosis index in patients with primary liver cancer. Method: 118 cases of patients with primary liver cancer as observation group and 100 cases of persons with health check-up as control group. After treatment for one week with TACE, compared coagulation function (APTT, PT and FIB), liver function (TBIL, DBIL, IBIL, ALB and ALT) and liver fibrosis indexes (LN, HA, PⅢP and ⅣC) in control group and observation group before and after treatment. Results: Levels of APTT, PT in observation group after treatment were higher than before treatment in group, moreover were lower than the control group, there was statistical significant difference, level of FIB after treatment in observation group was significantly lower than before treatment and obviously higher than control group, difference was significant; Compared with observation group before treatment, levels of TBIL, DBIL, IBIL, ALT increased dramatically, ALB level decreased obviously after treatment, moreover levels of TBIL, DBIL, IBIL, ALT in observation group before and after treatment were significant higher and ALB level was lower than that in control group, difference was significant; levels of LN, HA, PⅢP and ⅣC in observation group before and after treatment exceeded significantly in control group, levels of LN, HA, PⅢP and ⅣC after treatment was higher when compared with before treatment, the difference comparison was statistical significant. Conclusion: It could effectively improve coagulation function through treating primary liver cancer patients with TACE, however chemotherapy drug and embolotherapy would damage liver cells of patients and affect the liver function and liver fibrosis at some extent.