Osteomyelitis is an infection of the jaw that extends to the jaw bone, which is the spongy, bone marrow, cortex, and periosteum. Infection occurs in the calcified bone when fluid in the medullary cavity or under the periosteum interfere with the blood supply. In this case, it was reported an elderly patient with a diagnosis of chronic osteomyelitis of mandible edentulous dextra. The treatment were sequesterectomy and extraction the radix of tooth 43 by general anesthesia, and combinating with antibiotics. It was concluded that patient of chronic suppurative osteomyelitis of the mandible edentulus could be diagnosed through clinical and radiological examination, and successfully treated with sequesterectomy and extracting the radix under general anesthesia. So the improvement of systemic condition, food nutrition, vitamin therapy, accelerate the healing process. Treatment of focal infection as soon as possible to avoid more severe complications.