The analysis of psycho-autonomic status, urodynamics of lower urinary tract, the character of family education in children with various courses of primary night enuresis (PNE) was made. 198 children with PNE and 36 healthy children who formed the control group were examined. It was found out that children with PNE were observed to have detrusion-sphincter dissynergy and inadequate family education; the severity of enuresis correlated with the severity of minimal brain dysfunctions. Peculiarities of autonomic regulation in children with primary nocturnal enuresis were caused by stable increase of the parasympathetic nervous system tonus and decrease of the sympathetic nervous system tonus, the severity of the both increasing with the increase of the disease severity