Due to economic, technological, and cultural changes, low-cost home-based businesses have been reconsidered as a way to provide a sustainable income. A home-based business is a continuous activity, in the production or distribution of goods or services. It is carried out where people reside to earn a living. This study aims to identify the characteristics of home-based businesses in Iran, England, and India and then presents some solutions at the macro level for improving the conditions of home-based businesses with a focus on Iran conditions. In this study, we compared the similarities, differences, and characteristics of the home-based businesses, as well as the context in which they grow. This research with a comparative-descriptive approach and analyzing the current statistics, information, and policies analysis tries to recognize comparatively the influential factors on the sustainability and success of home-based businesses. Based on our research, although some solutions for the success of these businesses are related to the overall business environment, it is possible to improve their working conditions and access to different markets by taking some measures such as providing access to information resources, education, social networks, and financing, which are specific to these businesses.