There have been rare published cases of discoid lupus erythematosus (DLE) with other autoimmune cutaneous and systemic disorders. We describe a 36 years old female patient with DLE lesions on the face and hands with coexistence of lip-tip vitiligo and hypothyroidism. We discuss how the treatment has to be modified and innovative in the presence of these three coexisting autoimmune disorders and how the dermatologist should do this to get a successful outcome.