The implementation of some strategies such as DPSIR framework may lead to a better coordination at both local and national level with a view to maintaining biodiversity and quality of water bodies. The different sensibility of the benthic macroinvertebrates has been used in determining the manner in which these communities are being influenced by the socio-economic development, in the end modifying the biodiversity. The present study aims at presenting a list concerning the different species of caddisflies identified in the larva phase in Natura 2000 site Lower Gorge of Mureş river, to draw attention on existing threats regarding the quality of aquatic ecosystems based on the indentified caddisflies species and also to propose a series of conservation measures considered essential to the sustainable development of socio-ecological complexes in the target area. The sample collecting points were represented by 13 stations used to identify the caddisflies species in the larva phase. There were identified 20 species included in a number of 7 families. The most frequent species were Hydropsyche instabilis and Hydropsyche fulvipes (qualitative samples), and Hydropsyche instabilis, Hydropsyche fulvipes and Ecclisopteryx madida (quantitative samples), respectively.