Objective: the purpose of this research is to investigate the effect of hospital based cardiac rehabilitation on quality of life of patients with myocardial infarction, which have referred to Baghiatallah hospital in Tehran during the year of 2010. Materials & Methods: in this semi-experimental research, 50 patients with myocardial infarction in the form of sequential sampling for experimental group and control group in the form of matched probability group (based on age, sex and education) were divided into two groups. First group includes hospital based cardiac rehabilitation (n=25) and later control group (n=25). The information collected with demographic and MC New quality of life questionnaires .The rehabilitation program consisted of twenty session education program and cardiac rehabilitation program. To investigate the differences between experimental and control group, independent samples t-test and paired t-test were used. The education material included some information on diet, medication, coronary risk factors and explanation of the patient cardiac event and exercise. Results: the research finding indicates the improvement in quality of life for experimental group following the application of hospital based cardiac rehabilitation, this improvement includes all dimensions such as physical (P<0.05), psychological (P<0.05), social (P<0.05) and overall (P<0.05) aspects of quality of life. Conclusion: since there is no meaningful differences in quality of life between experimental and control groups before the application of hospital based cardiac rehabilitation, it can be concluded that this differences derived from hospital based cardiac rehabilitation.