Estrogen levels change closely related with IBS (irritable bowel syndrome) of the occurrence and development, estrogen play a regulatory role for IBS through various channels, such as emotional reactions, gastrointestinal motility, gastrointestinal hormones and brain - intestinal shaft. Estrogen receptors (ERs) of the gastrointestinal tract mainly in mast cells, intestinal allergy, infection can activate mast cells, a direct result of the clinical symptoms of IBS patients. Suggesting that mast cells in the gastrointestinal tract is likely to be involved in the pathogenesis of IBS estrogen important mediating link. In this paper, research of ERs estrogen and IBS were reviewed.