This research was aimed at providing evidence on climate change and health knowledge among adolescents. A cross-sectional study was conducted in Yogyakarta city from June to September 2016. A structured questionnaire was used to collect data among 508 adolescents who were in the second grade of a senior high school. This study revealed that participants had a low and inconsistent understanding regarding climate change and its impact on health. They reported that they prefer to get climate change information via talking with family. In summary, adolescent knowledge regarding climate change and health needs to improve with proper content and appropriate media.