Beyond the loss of peri-urban agricultural and forested land as a result of built-up expansion, not much information exists on the changes in the structure of the peri-urban landscape in Ghana. The aim of this paper is to examine the extent to which urban expansion is driving changes in landscape structure of the peri-urban fringes of Accra. We submit that rapid peri-urbanisation will fragment the existing agricultural and forested landscape with consequent ecological, socio-economic and urban governance implications. Using Landsat satellite images for the years 1985, 1991, 2002 and 2015 the study area was classified into four land cover classes. The study adopted the use of Urban Intensity Index (UII) and the Annual Rate of Urbanization (R) as measures of urbanization. Edge density (ED), largest patch index (LPI) and Aggregation index (AI) were used as proxies to measure landscape structural transformations. The study reveals substantial reductions and fragmentation in agricultural lands, riverine and open forests, while there has been over 200 percent increase in built-up areas. Beyond these revelations in spatiotemporal changes in landscape structure, the paper points to the ecological implications of the changes, and three key socio-economic and urban governance implications.