Compared Effects of Two Formulations of a Mineral Fertilizer on Yield and Mineral Nutrition of Cotton in Burkina Faso. The high cost of mineral fertilizers is the main constraint in cotton production. Experimentations were led during 2 years on 4 sites of cotton production area of Burkina Faso. The bulk formulation of cotton mineral fertilizer was compared to the complex formulation commonly used in cotton production. The experimental design is a block Fisher with 4 treatments and 6 replicates. The following treatments were applied: control without fertilizer, complex formulation of the mineral fertilizer, bulk blending formulation of the mineral fertilizer, local bulk formulation of the mineral fertilizer. N, P, K, S and B were respectively applied at constant rates of 44; 44.5; 21; 9 and 1.5 kg/ha on fertilized soils. The results showed that on acidic soils, with low organic matter content, no significant difference was obtained between the complex and the bulk formulation of the mineral fertilizer, with respect to the yields. Cotton mineral nutrition was supplied as well by the bulk as the complex formulation and this explained the high nutrition indexes (>100) for N, P and S. The bulk formulation with a lower cost than the complex formulation and an agronomic efficiency equivalent to that of the complex formulation, confirms the interest of using this formulation in cotton production.