The aim of the study was to develop a laboratory risk assessment methodology caries recurrence during pregnancy on the contents of the antimicrobial factor in innate immunity in oral fluid. Surveyed 207 pregnant women with caries of the teeth (clinical group), 31 a pregnant woman with no dental pathology and 32 healthy donors without physical and dental diseases. The patients in oral fluid determined three immune peptides: lactoferrin, cathelicidin LL-37 and α-defensin. In pregnant women the development of dental caries has been accompanied by increased in 2 trimester on trimester 1 level all immune peptides in saliva with the subsequent reduction in antimicrobial peptides α-defensin1-3 and cathelicidin LL37 in oral fluid in the 3 trimester. A compensatory mechanism for constraining the increase of intensity and activity of caries, the recurrence of the disease in pregnancy is increase antibacterial protein lactoferrin in saliva. In pregnant women during the first trimester of gestation when the oral fluid levels of lactoferrin above 3,08 g/ml, lowering the content of cathelicidin is below 1,9 pg/ml, caries recurrence risk goes up.