Based on the teachings of the Quran, sins and good deeds have impact on natural disasters and the fate of the human in the world. One of these natural factors is rain which from the perspective of science, requires a special climate condition to prepare the ground for its occurrence. But the Quran takes the spiritual factors involved in the formation of rain, and considers them as a stimulus for the natural factors. Due to the importance of the subject, the present article aims, with using descriptive-analytic methods, to examine raining and its spiritual factors from the perspective of the Quran. For this purpose, after studying the word of the rain and its functions, the relationship between spiritual factors and natural causes, based on the opinions of commentators, has been analyzed. And finally the article came to this conclusion that three factors of endurance in the religion of Allah, repentance and hopelessness from the apparent causes, were counted as the spiritual factors of raining.