METHODS: A retrospective study. Totally 108 cases(216 eyes)with high myopia received SMILE during March 2015 to October 2016 were involved. The IOP_NCT, corneal central thickness(CCT)and corneal curvature for 3mo were recorded and analyzed by ANOVA, LSD t test. The Pearson correlation analysis and multiple linear regression model analysis were used to evaluate the relationship between IOP_NCT and its influence factors.

RESULTS:(1)There was significant statistical difference in IOP_NCT after SMILE at 1d, 1wk, 1 and 3mo compare with preoperative(t=17.785, P=0.019; t=17.981, P=0.016; t=18.841, P=0.012; t=19.364, P=0.001); the IOP_NCT after SMILE decreased. The IOP_NCT values at every time after SMILE was no statistical difference(t=1.871, P=0.818; t=3.062, P=0.328; t=1.143, P=0.373).(2)The IOP_NCT in high myopia were positive correlated with CCT and corneal curvature after SMILE(r=0.4356, 0.295; PSymbol|@@0.05), respectively.(3)The multiple linear regression model analysis revealed that Y=-14.601+0.348X₁+0.03X₂(Y was IOP_NCT, X₁ was corneal curvature, X₂ was CCT,PSymbol|@@0.001); Y=3.679+0.28X₁+0.012X₂(Y was△IOP_NCT,X₁ was variation of corneal curvature,X₂ was△CCT, PSymbol|@@0.001).

CONCLUSION: The IOP_NCT decreased after SMILE in high myipia, and it showed that there was no significant influence to use glucocorticoid eye drops in short terms. There was positive correlation among IOP_NCT, CCT and corneal curvature after SMILE.