ABSTRACT: Plants density in soybean cultivation is an important management practice to achieve high grain yield. In this way, the objective was to evaluate the agronomic traits and grain yield in soybean in different plant densities, in two locations in the south of Minas Gerais. The experimental design was in randomized blocks, arranged in a split plot design, with three replications. Plots were composed of four population densities (300, 400, 500 and 600 thousand plants per hectare) and the subplots were composed of six cultivars (‘BMX Força RR’, ‘CD 250 RR’, ‘FMT 08 - 60.346/1’, ‘NA 5909 RR’, ‘TMG 7161 RR’ and ‘V - TOP RR’) grown in Lavras and Inconfidentes, both in Minas Gerais. At the time of harvest was determined the plant height, lodging, insertion of the first pod, harvest index, number of pods per plant, number of grains, number of grains per pod and yield. Regardless of the soybean cultivar, the plant density of up to 600,000 per ha does not affect grain yield, plant height, lodging, harvest index, and number of grains per pod. The cultivars ‘V-TOP RR’ and ‘BMX FORÇA RR’ showed high grain yield and good agronomic traits in Lavras and Incofidentes.