Forming functional fat: a growing understanding of adipocyte differentiation
Abstract
Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of mesenchymal stem cells to a preadipocyte fate and terminal differentiation. Cell shape and extracellular matrix remode …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
N.I.H.
Extramural
Adipocytes / physiology*
Transforming Growth Factor beta / physiology
mesenchymal stem cells / cytology
adipocytes / cytology*
biological
cell differentiation / physiology
signal transduction
cell differentiation / genetics
epigenesis
ppar gamma / genetics
adipogenesis / physiology*
pmid:21952300
pmc7171550
doi:10.1038/nrm3198
ana g cristancho
mitchell a lazar
adipogenesis / genetics
ccaat-enhancer-binding proteins / physiology
cell lineage
cell shape
extracellular matrix / physiology
mesenchymal stem cells / physiology
ppar gamma / physiology
wnt signaling pathway
rho gtp-binding proteins / physiology
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120976
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