Evaluation of the antiviral activity of N-(phosphonoacetyl)-L-aspartate against paramyxoviruses in tissue culture and against respiratory syncytial virus in cotton rats
Abstract
N-(phosphonoacetyl)-L-aspartate (PALA), a potent inhibitor of L-aspartic acid transcarbamoylase, was evaluated for cytotoxicity and antiviral activity against three different paramyxoviruses in tissue culture, and for antiviral efficacy and toxicity in vivo using a cotton rat-respiratory syncytial v …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
female
male
Cultured
Rats
p r wyde
d k moore
evaluation studies as topic
sigmodontinae
dogs
chlorocebus aethiops
respiratory syncytial viruses / drug effects*
vero cells
antiviral agents / pharmacology*
human / drug effects
molecular structure
tumor cells
parainfluenza virus 3
pmid:7486959
doi:10.1016/0166-3542(94)00080-r
h a blough
aspartic acid / analogs & derivatives*
aspartic acid / pharmacology
measles virus / drug effects
phosphonoacetic acid / analogs & derivatives*
phosphonoacetic acid / pharmacology
respirovirus / drug effects*
toxicity tests
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Citation
ID:
120657
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