An Antibody Designed to Improve Adoptive NK-Cell Therapy Inhibits Pancreatic Cancer Progression in a Murine Model
Abstract
Natural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer. Despite the usefulness of NK cells, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antit …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
treatment outcome
research support
non-u.s. gov't
female
Disease Models
Animal
Antibodies
cell line
immunotherapy
monoclonal / pharmacology*
combined modality therapy
disease progression
pancreatic neoplasms / pathology
pmid:30514792
doi:10.1158/2326-6066.cir-18-0317
jaemin lee
tae heung kang
seokho kim
chemotaxis / drug effects
chemotaxis / immunology
immunoconjugates / pharmacology
adoptive* / methods
killer cells
natural / immunology*
natural / metabolism
pancreatic neoplasms / immunology*
pancreatic neoplasms / mortality
pancreatic neoplasms / therapy*
xenograft model antitumor assays
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120634
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