Pharmacodynamics of levofloxacin and ciprofloxacin in a murine pneumonia model: peak concentration/MIC versus area under the curve/MIC ratios
Abstract
During the last decade some studies have shown that the area under the curve (AUC)/MIC ratio is the pharmacodynamic index that best predicts the efficacies of quinolones, while other studies suggest that the predictive value of the peak concentration/MIC (peak/MIC) ratio is superior to the AUC/MIC r …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
Survival Analysis
pneumonia
pneumococcal / microbiology
microbial sensitivity tests
anti-infective agents / therapeutic use
ciprofloxacin / therapeutic use
microbial
dose-response relationship
drug
levofloxacin*
area under curve
ofloxacin / therapeutic use
protein binding
colony count
anti-infective agents / pharmacokinetics*
streptococcus pneumoniae / drug effects
pneumococcal / drug therapy
pmid:12936969
pmc182632
doi:10.1128/aac.47.9.2749-2755.2003
f scaglione
j w mouton
f fraschini
ciprofloxacin / pharmacokinetics*
ofloxacin / pharmacokinetics*
pneumococcal / metabolism*
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120431
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