Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
Abstract
Testosterone supplementation in men decreases fat mass; however, the mechanisms by which it inhibits fat mass are unknown. We hypothesized that testosterone inhibits adipogenic differentiation of preadipocytes by activation of androgen receptor (AR)/beta-catenin interaction and subsequent translocat …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
N.I.H.
Extramural
Adipose Tissue / cytology*
3T3 Cells
Adipocytes / drug effects
Cell Differentiation / drug effects
Receptors
Messenger / genetics
gene expression regulation / drug effects
genetic / drug effects
transcription
transcription factors / genetics*
adipocytes / cytology*
signal transduction / physiology
testosterone / pharmacology*
reverse transcriptase polymerase chain reaction
wnt proteins / genetics
wnt proteins / physiology*
protein transport / drug effects
pmid:16210377
pmc4417624
doi:10.1210/en.2004-1649
rajan singh
jorge n artaza
shalender bhasin
cell nucleus / metabolism*
androgen / metabolism*
tcf transcription factors / metabolism*
transcription factor 7-like 2 protein
beta catenin / metabolism*
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120307
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