1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase
Abstract
α-Fluorinated-1,1-bisphosphonic acids derived from fatty acids were designed, synthesized and biologically evaluated against Trypanosoma cruzi, the etiologic agent of Chagas disease, and against Toxoplasma gondii, the agent responsible for toxoplasmosis, and also towards the target parasitic enzymes …
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National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
N.I.H.
Extramural
enzyme inhibitors / pharmacology*
diphosphonates / chemistry
valeria s rosso
sergio h szajnman
juan b rodriguez
diphosphonates / pharmacology*
geranyltranstransferase / antagonists & inhibitors*
geranyltranstransferase / metabolism
pmid:22215028
pmc3458512
doi:10.1039/c1ob06602a
antiprotozoal agents / chemistry
antiprotozoal agents / pharmacology*
enzyme inhibitors / chemistry
toxoplasma / enzymology*
toxoplasma / metabolism
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