The purpose of establishing a tailings dam is to safely store tailings to protect the natural environment from damage. Accidents at tailings dams are frequent, however, with serious consequences of not only threats to life and property but also the pollution of the environment. Many tailings dam accidents are caused by seepage failure. In this paper, the object of the case study is the Lixi tailings dam. Three- and two-dimensional finite element models are established. The seepage field of the project under different working conditions is simulated and the position of the phreatic line is obtained. The safety factors under different working conditions are obtained by combining the seepage field with the stable surface. Finally, the influence of different dry and upstream slope ratio on seepage and stability of tailings dam is obtained. The results show that the longer the length of the dry beach, the lower the phreatic line and the greater the safety factor. The higher the upstream slope ratio, the lower the phreatic line and the greater the safety factor.