Synthesis and antiviral activity of benzyl-substituted imidazo [1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives
Abstract
A variety of imidazo[1,5-a]-1,3,5-triazine derivatives carrying C-, O-, and S-benzyl and/or 4-methylbenzyl groups were synthesized and examined for their inhibitory effects on the replication of ortho- and paramyxoviruses. The key compounds 8-R-2-thioxo-2,3-dihydroimidazo [1,5-a]-1,3,5-triazin-4(1H) …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cell line
chlorocebus aethiops
vero cells
e de clercq
antiviral agents / pharmacology*
hela cells
hiv-1 / drug effects
hiv-2 / drug effects
human / drug effects
respiratory syncytial viruses / drug effects
structure-activity relationship
parainfluenza virus 3
influenza a virus / drug effects
pmid:7658442
doi:10.1021/jm00018a015
b golankiewicz
p januszczyk
antiviral agents / chemical synthesis
drug screening assays
antitumor
imidazoles / chemical synthesis
imidazoles / pharmacology*
rna viruses / drug effects
triazines / chemical synthesis
triazines / pharmacology*
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119801
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