Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells
Abstract
1,4-Naphthoquinone and its derivatives have shown some efficacy as therapeutic compounds for cancer and inflammation, though their clinical application is limited by their side-effects. To reduce the toxicity of these compounds and optimize their effects, we synthesized two 1,4-naphthoquinone deriva …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cell line
carcinoma
proto-oncogene proteins c-akt / metabolism*
apoptosis / drug effects*
reactive oxygen species / metabolism*
hepatocellular / pathology
liver neoplasms / pathology
cheng-hao jin
naphthoquinones / pharmacology*
gui-nan shen
pmid:29326072
doi:10.1016/j.biocel.2018.01.004
chang liu
hepatocellular / drug therapy
hepatocellular / metabolism*
liver neoplasms / drug therapy
liver neoplasms / metabolism*
map kinase signaling system / drug effects*
naphthoquinones / chemistry
stat3 transcription factor / metabolism*
p38 mitogen-activated protein kinases / metabolism*
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119377
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