Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis

Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis

Liang X;Tao C;Pan J;Zhang L;Liu L;Zhao Y;Fan Y;Cao C;Liu J;Zhang J;Lam SM;Shui G;Jin W;Li W;Zhao J;Li K;Wang Y;;
protein & cell 2020 pp. -
241
x2020proteinrnf20

Abstract

RNF20, an E3 ligase critical for monoubiquitination of histone H2B at lysine 120 (H2Bub), has been implicated in the regulation of various cellar processes; however, its physiological roles in adipocytes remain poorly characterized. Here, we report that the adipocyte-specific knockout of Rnf20 (ASKO …

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