A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
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A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

Korkut A;Zaidi S;Kanchi RS;Rao S;Gough NR;Schultz A;Li X;Lorenzi PL;Berger AC;Robertson G;Kwong LN;Datto M;Roszik J;Ling S;Ravikumar V;Manyam G;Rao A;Shelley S;Liu Y;Ju Z;Hansel D;de Velasco G;Pennathur A;Andersen JB;O'Rourke CJ;Ohshiro K;Jogunoori W;Nguyen BN;Li S;Osmanbeyoglu HU;Ajani JA;Mani SA;Houseman A;Wiznerowicz M;Chen J;Gu S;Ma W;Zhang J;Tong P;Cherniack AD;Deng C;Resar L; ;Weinstein JN;Mishra L;Akbani R;;
cell systems 2018 Vol. 7 pp. -
317
a2018cella

Abstract

We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode mediators and regulators of TGF-β signaling, we found at lea …

Keywords

National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't non-p.h.s. N.I.H. Extramural signal transduction* neoplasms / genetics* micrornas / genetics smad proteins / metabolism dna methylation anil korkut rehan akbani receptor pmid:30268436 pmc6370347 doi:10.1016/j.cels.2018.08.010 sobia zaidi bone morphogenetic protein 5 / genetics bone morphogenetic protein 5 / metabolism mutation rate* transforming growth factor-beta type i / genetics transforming growth factor-beta type i / metabolism smad proteins / genetics transforming growth factor beta / genetics transforming growth factor beta / metabolism*

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