Inhibiting the urokinase-type plasminogen activator receptor system recovers STZ-induced diabetic nephropathy
Abstract
The urokinase-type plasminogen activator (uPA) receptor (uPAR) participates to the mechanisms causing renal damage in response to hyperglycaemia. The main function of uPAR in podocytes (as well as soluble uPAR -(s)uPAR- from circulation) is to regulate podocyte function through αvβ3 integrin/Rac-1. …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
Rats
Sprague-Dawley
Receptors
signal transduction / physiology
diabetes mellitus
massimo dal monte
inflammation / metabolism
up-regulation / physiology
maurizio cammalleri
paola bagnoli
pmid:30426662
pmc6349167
doi:10.1111/jcmm.14004
experimental / chemically induced
experimental / metabolism*
diabetic nephropathies / chemically induced*
diabetic nephropathies / metabolism*
kidney / metabolism
podocytes / metabolism
urokinase plasminogen activator / metabolism*
streptozocin / pharmacology*
urokinase-type plasminogen activator / metabolism
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118797
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