In this work we propose a facile method of preparing cost-effective clay-metaloxide/metal (CuO/Ag and ZnO/Ag) composite pellets for an efficient water purification technique. Clay, with intrinsic antibacterial activity, served as a membrane support for different metaloxide/Ag nanoparticles (NPs) concentrations (2.5, 5 and 10 wt.%), as the active fillers. The effect of time (24 and 48 h) on the bactericidal activity of these pellets was also monitored. The clay–nanocomposite pellets were characterized using: X-ray diffraction, X-ray fluorescence, scanning electron microscopy, transmission electron microscopy, ultraviolet–visible (UV–Vis) spectrophotometry and nitrogen desorption analysis. The antibacterial activity performance was tested using E. coli and S. aureus strains of ATCC25922 and ATCC25923, respectively, in two aqueous media (nutrient broth and nutrient-free) by the colony-forming unit method. The results showed that the clay-CuO/Ag composite with a bandgap (1.24 eV) exhibited overall best performance under all conditions and time factors of ~100% efficiency in nutrient-free medium for all concentrations and times and 20–40% efficiency in nutrient broth for 24 h. The clay-ZnO/Ag with a bandgap of 2.88 eV showed no bactericidal activity in both media, except for that with 10 wt.% ZnO/Ag which showed 100% efficiency in nutrient-free medium after 24 h. All the synthesized composites showed 100% bactericidal efficiency in nutrient free medium after 48 h. These results indicate that, the clay/metaloxide/Ag could serve as efficient water purification technique, with a potential for large-scale commercialization.