Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

Houri-Zeevi L;Korem Kohanim Y;Antonova O;Rechavi O;;
Cell 2020 Vol. 182 pp. -
162
l2020cellthree

Abstract

Experiences trigger transgenerational small RNA-based responses in C. elegans nematodes. Dedicated machinery ensures that heritable effects are reset, but how the responses segregate in the population is unknown. We show that isogenic individuals differ dramatically in the persistence of transgenera …

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