Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity
Abstract
Mice deficient in C/EBP alpha have defective development of adipose tissue, but the precise role of C/EBP alpha has not been defined. Fibroblasts from C/EBP alpha(-/-) mice undergo adipose differentiation through expression and activation of PPAR gamma, though several clear defects are apparent. C/E …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
Post-Translational
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
P.H.S.
enhancer elements
Adipose Tissue / metabolism*
Lipid Metabolism
Knockout
Promoter Regions
e d rosen
glucose / metabolism
cell differentiation
insulin resistance / physiology*
b m spiegelman
phosphoproteins / biosynthesis
phosphorylation
fibroblasts / cytology
protein processing
adipose tissue / cytology
phosphoproteins / genetics
insulin / physiology*
pmid:10078198
doi:10.1016/s1097-2765(00)80306-8
z wu
adipose tissue / drug effects
fibroblasts / drug effects
fibroblasts / pathology*
insulin / pharmacology
insulin receptor substrate proteins
receptor
insulin / biosynthesis
insulin / genetics
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118268
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