GSK-3β inhibition confers cardioprotection associated with the restoration of mitochondrial function and suppression of endoplasmic reticulum stress in sevoflurane preconditioned rats following ischemia/reperfusion injury
Abstract
Taken together, the findings obtained from the study support the concept that sevoflurane preconditioning confers cardioprotection against myocardial I/R injury and GSK-3β/β-catenin signaling activation mediated by TDZD-8 as a novel target to prolong cardioprotection by sevoflurane anaesthesia.
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
Cardiotonic Agents / pharmacology*
Glycogen Synthase Kinase 3 beta / metabolism
Rats
Sprague-Dawley
enzyme inhibitors / pharmacology*
signal transduction / drug effects*
mitochondria
myocardium / pathology
pmid:29987974
doi:10.1177/0267659118787143
yujia wang
chunlin ge
jianjun liu
endoplasmic reticulum stress / drug effects
glycogen synthase kinase 3 beta / antagonists & inhibitors*
heart / enzymology*
heart / pathology
myocardial reperfusion injury / drug therapy*
myocardial reperfusion injury / enzymology
myocardial reperfusion injury / pathology
myocardium / enzymology
sevoflurane / pharmacology*
thiadiazoles / pharmacology*
beta catenin / metabolism
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118080
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