Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys
Abstract
This study determined whether timing of prenatal androgen excess resulted in differential impairment of insulin-glucose homeostasis in adult female rhesus monkeys. Ten female rhesus monkeys exposed to testosterone propionate starting on gestational day 40 (early treated), 9 females exposed to testos …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
non-u.s. gov't
u.s. gov't
female
gestational age*
P.H.S.
d a dumesic
d h abbott
body mass index
Blood Glucose / metabolism
macaca mulatta
testosterone / pharmacology*
prenatal exposure delayed effects*
glucose tolerance test
insulin / blood
insulin secretion
insulin / metabolism*
pmid:10720063
doi:10.1210/jcem.85.3.6453
j r eisner
insulin / physiology*
islets of langerhans / drug effects
islets of langerhans / physiology
ovulation / physiology
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118015
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