Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa
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Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa

Hakim J;Musiime V;Szubert AJ;Mallewa J;Siika A;Agutu C;Walker S;Pett SL;Bwakura-Dangarembizi M;Lugemwa A;Kaunda S;Karoney M;Musoro G;Kabahenda S;Nathoo K;Maitland K;Griffiths A;Thomason MJ;Kityo C;Mugyenyi P;Prendergast AJ;Walker AS;Gibb DM; ;;
The New England journal of medicine 2017 Vol. 377 pp. -
278
j2017theenhanced

Abstract

Among HIV-infected patients with advanced immunosuppression, enhanced antimicrobial prophylaxis combined with ART resulted in reduced rates of death at both 24 weeks and 48 weeks without compromising viral suppression or increasing toxic effects. (Funded by the Medical Research Council and others; R …

Keywords

National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine adult female male adolescent aged middle aged young adult Child Randomized Controlled Trial Multicenter Study drug therapy combination africa south of the sahara / epidemiology trimethoprim cd4 lymphocyte count anti-retroviral agents / therapeutic use* hiv infections / drug therapy* kaplan-meier estimate anti-infective agents / adverse effects anti-infective agents / therapeutic use* hiv infections / mortality reality trial team sulfamethoxazole drug combination / therapeutic use pmid:28723333 pmc5603269 doi:10.1056/nejmoa1615822 james hakim victor musiime aids-related opportunistic infections / prevention & control* anti-retroviral agents / adverse effects isoniazid / therapeutic use pyridoxine / therapeutic use

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http://www.ncbi.nlm.nih.gov/pubmed/28723333

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Ref Key: j2017theenhanced
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