The main aim of this study is to assess groundwater potential of the DakNong province, Vietnam, using an advanced ensemble machine learning model (RABANN) that integrates Artificial Neural Networks (ANN) with RealAdaBoost (RAB) ensemble technique. For this study, twelve conditioning factors and wells yield data was used to create the training and testing datasets for the development and validation of the ensemble RABANN model. Area Under the Receiver Operating Characteristic (ROC) curve (AUC) and several statistical performance measures were used to validate and compare performance of the ensemble RABANN model with the single ANN model. Results of the model studies showed that both models performed well in the training phase of assessing groundwater potential (AUC ≥ 0.7), whereas the ensemble model (AUC = 0.776) outperformed the single ANN model (AUC = 0.699) in the validation phase. This demonstrated that the RAB ensemble technique was successful in improving the performance of the single ANN model. By making minor adjustment in the input data, the ensemble developed model can be adapted for groundwater potential mapping of other regions and countries toward more efficient water resource management. The present study would be helpful in improving the groundwater condition of the area thus in solving water borne disease related health problem of the population.