cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Abstract
Geographic atrophy is a blinding form of age-related macular degeneration characterized by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, resultant accumulation of endogenous Alu-retroelement RNA, and NLRP3-inflammasome activation. How the inflammasome is activate …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
N.I.H.
Extramural
signal transduction
shinichi fukuda
pmid:29176737
pmc5760363
doi:10.1038/nm.4450
nagaraj kerur
jayakrishna ambati
dead-box rna helicases / genetics
geographic atrophy / enzymology*
inflammasomes / metabolism*
interferon type i / metabolism
nucleotidyltransferases / metabolism*
retinal pigment epithelium / metabolism
ribonuclease iii / genetics
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117840
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