Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing
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Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

Maynard A;McCoach CE;Rotow JK;Harris L;Haderk F;Kerr DL;Yu EA;Schenk EL;Tan W;Zee A;Tan M;Gui P;Lea T;Wu W;Urisman A;Jones K;Sit R;Kolli PK;Seeley E;Gesthalter Y;Le DD;Yamauchi KA;Naeger DM;Bandyopadhyay S;Shah K;Cech L;Thomas NJ;Gupta A;Gonzalez M;Do H;Tan L;Bacaltos B;Gomez-Sjoberg R;Gubens M;Jahan T;Kratz JR;Jablons D;Neff N;Doebele RC;Weissman J;Blakely CM;Darmanis S;Bivona TG;;
Cell 2020 Vol. 182 pp. -
180
a2020celltherapy-induced

Abstract

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) of metastatic lung cancer was performed using 49 clinical biopsies obtained from 30 patients b …

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National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine pmid:32822576 doi:10.1016/j.cell.2020.07.017 ashley maynard caroline e mccoach trever g bivona

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