IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression
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IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

Sadik A;Somarribas Patterson LF;Öztürk S;Mohapatra SR;Panitz V;Secker PF;Pfänder P;Loth S;Salem H;Prentzell MT;Berdel B;Iskar M;Faessler E;Reuter F;Kirst I;Kalter V;Foerster KI;Jäger E;Guevara CR;Sobeh M;Hielscher T;Poschet G;Reinhardt A;Hassel JC;Zapatka M;Hahn U;von Deimling A;Hopf C;Schlichting R;Escher BI;Burhenne J;Haefeli WE;Ishaque N;Böhme A;Schäuble S;Thedieck K;Trump S;Seiffert M;Opitz CA;;
Cell 2020 Vol. 182 pp. -
153
a2020cellil4i1

Abstract

Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation of AHR activity and its upstream enzymes across human cancers. A pan-tissue …

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National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine pmid:32818467 doi:10.1016/j.cell.2020.07.038 ahmed sadik luis f somarribas patterson christiane a opitz

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