One case of epileptogenic circumscribed meningo-encephalitis with calcification is presented. Histological and histochemical investigations have been performed and the following enzyme activities were studied: DPN and TPN Diaphorases, succinic, lactic-, glucose-6-phosphate- and DPN and TPN linked isocitric-dehydrogenase, alkaline and acid phosphatases and ATP-phosphatase. A relation between enzyme activities and calcification was investigated. ATP-ase was found to be increased in the vessels with concrements and around concretions. No other enzyme activity showed a positive relation to calcification, but it can not be excluded that alkaline phosphatase participates in the process. Reactive astrocytes and oligodendrocytes showed a pattern of Tetrazolium reduction similar to that observed in other pathological conditions.