'Self' tolerance in a parent-->F1 radiation chimera
Abstract
The extent to which T cell immune tolerance to self tissue antigens is acquired during intrathymic development, or also may occur elsewhere in the animal, remains unclear. Experiments have been designed to explore this using allogeneic hematopoietic radiation chimeras in which thymectomized CB6F1 (H …
Keywords
radiation
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
female
male
P.H.S.
Cells
Cultured
Inbred BALB C
research design
t-lymphocytes / immunology*
pmid:10579396
doi:10.1016/s0145-305x(99)00048-8
j r klein
graft vs host disease / immunology
h-2 antigens / biosynthesis
h-2 antigens / immunology*
hematopoietic stem cells / immunology
histocompatibility antigen h-2d
histocompatibility antigens class ii / immunology
isoantigens / biosynthesis
isoantigens / immunology*
inbred c3h
self tolerance / immunology*
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117581
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