Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen
Abstract
The ability of the thymus to generate a population of T cells that is, for the most part, self-restricted and self-tolerant depends to a great extent on the Ags encountered during differentiation. We recently showed that mycobacteria disseminate to the thymus, which raised the questions of how mycob …
Keywords
image processing
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
fluorescent antibody technique
nude
computer-assisted
flow cytometry
t-lymphocytes / immunology*
immune tolerance / immunology*
tuberculosis / immunology*
pmid:19949112
doi:10.4049/jimmunol.0902152
claudia nobrega
susana roque
margarida correia-neves
cell differentiation / immunology
mycobacterium avium / immunology
t-lymphocytes / cytology
thymus gland / immunology
thymus gland / microbiology*
tuberculosis / veterinary
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117496
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